Details of the Drug

General Information of Drug (ID: DM1LM7D)

Drug Name

Mannose phosphate

Synonyms

MANNOSE PHOSPHATE; SCHEMBL285569; SB17274

Indication

Disease Entry	ICD 11	Status	REF
Lesion	8A00-8C12	Discontinued in Phase 2	[1]

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski):
1

Molecular Weight

278.15

Topological Polar Surface Area

Not Available

Rotatable Bond Count

5

Hydrogen Bond Donor Count

8

Hydrogen Bond Acceptor Count

10

Chemical Identifiers

Formula: C6H15O10P
IUPAC Name: (2S,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid
Canonical SMILES: C([C@H]([C@H]([C@@H]([C@@H](C=O)O)O)O)O)O.OP(=O)(O)O
InChI: InChI=1S/C6H12O6.H3O4P/c7-1-3(9)5(11)6(12)4(10)2-8;1-5(2,3)4/h1,3-6,8-12H,2H2;(H3,1,2,3,4)/t3-,4-,5-,6-;/m1./s1
InChIKey: NDVRKEKNSBMTAX-MVNLRXSJSA-N

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transforming growth factor beta 1 (TGFB1)	TTR9XHZ	TGFB1_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Lesion

ICD Disease Classification

8A00-8C12

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Transforming growth factor beta 1 (TGFB1)	DTT	TGFB1	5.95E-09	1.68	7.81

Molecular Expression Atlas (MEA)

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References

1	Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity. PLoS One. 2014 Oct 14;9(10):e110345.
2	The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. Immunol Lett. 2015 Jun;165(2):90-101.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Clinical pipeline report, company report or official report of Tissue Gene, Inc.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Perspectives of TGF-beta inhibition in pancreatic and hepatocellular carcinomas. Oncotarget. 2014 January; 5(1): 78-94.
7	Clinical pipeline report, company report or official report of Scholar Rock.
8	Clinical pipeline report, company report or official report of AbbVie.
9	Pharmaceutical products of TORREYA partners. December 2011.